Tuberous sclerosis complex: a brave new world?

A Brave New Integration World

Brave New World

Scientific publishing began in 1665 with the inauguration of the Journal des sçavans in France and the Philosophical Transactions of the Royal Society in England. These enterprises established the pattern that has endured to the present: that of a learned publication, financed privately, which shared knowledge within a select circle. By recording a date of publication, claims of scientific prio...

Brave New World

Written in 1931 and published the following year, Aldous Huxley’s Brave New World is a dystopian—or anti-utopian—novel. In it, the author questions the values of 1931 London, using satire and irony to portray a futuristic world in which many of the contemporary trends in British and American society have been taken to extremes. Though he was already a best-selling author, Huxley achieved intern...

Brave new RNA world.

In 1995, you could still find, in the opening paragraphs of manuscripts and grant applications from my lab and others, the phrase “In the absence of a crystal structure for the ribosome....,” by way of rationalizing any number of biochemical studies aimed at figuring out the three-dimensional locations of things inside the ribosome, and ultimately its mechanism. We no longer have this excuse. T...

The tuberous sclerosis complex.

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder that results from mutations in the TSC1 or TSC2 genes and is associated with hamartoma formation in multiple organ systems. The neurological manifestations of TSC are particularly challenging and include infantile spasms, intractable epilepsy, cognitive disabilities, and autism. Progress over the past 15 years has demonstrated t...